IDiyas

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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10696694 B1

PDFFull Text
Date of Patent:
Jun. 30, 2020

Filed:

Dec. 16, 2016

Lanthanide complexes for crystallising biological macromolecules and determining the crystallographic structure thereof

Applicants:

Ecole Normale Superieure DE Lyon, Lyons, FR;

Universite Claude Bernard Lyon I, Villeurbanne, FR;

Centre National DE LA Recherche Scientifique, Paris, FR;

Commissariat a L'energie Atomique ET Aux Energies Alternatives, Paris, FR;

Inventors:

Oliver Maury, Brindas, FR;

Eric Girard, Romans sur Isere, FR;

Sylvain Engilberge, Reignier, FR;

François Riobe, Lyons, FR;

Assignees:

ECOLE NORMALE SUPERIEURE LE LYON, Lyons, FR;

UNIVERSITE CLAUDE BERNARD LYON I, Villeurbanne, FR;

CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE, Paris, FR;

COMMISSARIAT A L'ENERGIE ATOMIQUE ET AUX ENERGIES ALTERNATIVES, Paris, FR;

Attorney:

Clark & Brody LP

Primary Examiner:

Michael G Hartley

Assistant Examiner:

Jagadishwar R Samala

Int. Cl.
CPC ...
C07F 5/00 (2006.01); G01N 23/22 (2018.01); C07D 401/14 (2006.01); G01N 23/223 (2006.01); C07D 413/14 (2006.01); B01D 9/00 (2006.01); C30B 7/14 (2006.01); C30B 29/58 (2006.01);
U.S. Cl.
CPC ...
C07F 5/003 (2013.01); B01D 9/005 (2013.01); C07D 401/14 (2013.01); C07D 413/14 (2013.01); C30B 7/14 (2013.01); C30B 29/58 (2013.01); G01N 23/223 (2013.01);
Abstract

The invention relates to cationic complexes made up of a lanthanide ion Ln3+ and a ligand of formula (I): with X, Y and R1 as defined in claim, and to the salts thereof with an anion, the solvates and hydrates thereof;with the exception of cationic complexes made up of a lanthanide ion Ln3+ and a ligand of one of formulae (I.1) or (I.4) as defined in claim, and the salts, solvates and hydrates thereof. The invention also relates to the use of such a complex or of a cationic complex made up of a lanthanide ion Ln3+ and a ligand of formula (I.1) or (I.4) as defined in claim, or of one of the salts thereof with an anion, the solvates or hydrates thereof, as an aid to the crystallisation of a biological macromolecule, as well as to crystallisation methods and methods for analysing or determining the structure of a biological macromolecule.

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