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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10696655 B1

PDFFull Text
Date of Patent:
Jun. 30, 2020

Filed:

Nov. 21, 2018

Therapeutic compounds and uses thereof

Applicants:

Genentech, Inc., South San Francisco, CA (US);

Constellation Pharmaceuticals, Inc., Cambridge, MA (US);

Inventors:

Patrick Cyr, South San Francisco, CA (US);

Sarah Bronner, South San Francisco, CA (US);

F. Anthony Romero, South San Francisco, CA (US);

Steven Magnuson, South San Francisco, CA (US);

Vickie Hsiao-Wei Tsui, South San Francisco, CA (US);

John Wai, Shanghai, CN;

Kwong Wah Lai, Shanghai, CN;

Fei Wang, Shanghai, CN;

Assignees:

GENENTECH, INC., South San Francisco, CA (US);

CONSTELLATION PHARMACEUTICALS, INC., Cambridge, MA (US);

Attorney:

Viksnins Harris Padys Malen LLP

Primary Examiner:

Bruck Kifle

Int. Cl.
CPC ...
C07D 223/16 (2006.01); C07D 243/12 (2006.01); C07D 243/14 (2006.01); C07D 267/14 (2006.01); C07D 403/04 (2006.01); C07D 403/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01); C07D 413/04 (2006.01); C07D 417/14 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 471/04 (2006.01); C07D 487/04 (2006.01); C07D 413/10 (2006.01); A61K 31/435 (2006.01); A61K 31/437 (2006.01); A61K 31/4375 (2006.01); A61K 31/496 (2006.01); A61K 31/4985 (2006.01); A61K 31/5025 (2006.01); A61K 31/519 (2006.01); A61K 31/5377 (2006.01); A61K 31/5513 (2006.01); A61K 45/06 (2006.01); C07D 487/22 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61K 31/435 (2013.01); A61K 31/437 (2013.01); A61K 31/4375 (2013.01); A61K 31/496 (2013.01); A61K 31/4985 (2013.01); A61K 31/5025 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/5513 (2013.01); A61K 45/06 (2013.01); C07D 243/14 (2013.01); C07D 267/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 413/04 (2013.01); C07D 413/10 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 487/22 (2013.01);
Abstract

The present invention relates to compounds of formula (I) and formula (II): and to salts thereof, wherein R-Rof formula (I) and R-Rof formula (II) have any of the values defined herein, and compositions and uses thereof. The compounds are useful as inhibitors of CBP and/or EP300. Also included are pharmaceutical compositions comprising a compound of formula (I) of formula (II), or a pharmaceutically acceptable salt thereof, and methods of using such compounds and salts in the treatment of various CBP and/or EP300-mediated disorders.

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