The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2020
Filed:
May. 31, 2018
Applicant:
The Government of the Usa As Represented BY the Secretary of the Dept. of Health and Human Services, Atlanta, GA (US);
Inventors:
Olen M. Kew, Alpharetta, GA (US);
Cara Carthel Burns, Avondale Estates, GA (US);
Jing Shaw, Decatur, GA (US);
Raymond Campagnoli, Decatur, GA (US);
Jacqueline Quay, Chapel Hill, NC (US);
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 39/04 (2006.01); A61K 39/108 (2006.01); A61K 39/00 (2006.01); C07K 14/245 (2006.01); C12N 15/67 (2006.01); C12N 7/00 (2006.01);
U.S. Cl.
CPC ...
A61K 39/0258 (2013.01); A61K 39/00 (2013.01); C07K 14/245 (2013.01); C12N 7/00 (2013.01); C12N 15/67 (2013.01); A61K 2039/522 (2013.01); A61K 2039/5254 (2013.01); C12N 2710/16162 (2013.01); C12N 2710/16662 (2013.01); C12N 2710/16762 (2013.01); C12N 2760/16162 (2013.01); C12N 2760/18462 (2013.01); C12N 2760/18562 (2013.01); C12N 2770/20062 (2013.01); C12N 2770/24162 (2013.01); C12N 2770/32162 (2013.01); C12N 2770/32762 (2013.01); C12N 2770/36262 (2013.01); Y02A 50/466 (2018.01); Y02A 50/472 (2018.01); Y02A 50/476 (2018.01);
Abstract
Methods of producing a pathogen with reduced replicative fitness are disclosed, as are attenuated pathogens produced using the methods. In particular examples, the method includes deoptimizing one or more codons in a coding sequence, thereby reducing the replicative fitness of the pathogen. Methods of using the attenuated pathogens as immunogenic compositions are also disclosed.