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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10695357 B1

PDFFull Text
Date of Patent:
Jun. 30, 2020

Filed:

Feb. 12, 2019

Methods for treating filoviridae virus infections

Applicant:

Gilead Sciences, Inc., Foster City, CA (US);

Inventors:

Byoung Kwon Chun, Pleasanton, CA (US);

Michael O'Neil Hanrahan Clarke, Redwood City, CA (US);

Edward Doerffler, Union City, CA (US);

Hon Chung Hui, San Mateo, CA (US);

Robert Jordan, Foster City, CA (US);

Richard L. Mackman, Millbrae, CA (US);

Jay P. Parrish, El Dorado Hills, CA (US);

Adrian S. Ray, Burlingame, CA (US);

Dustin Siegel, Half Moon Bay, CA (US);

Assignee:

GILEAD SCIENCES, INC., Foster City, CA (US);

Attorney:

Mintz, Levin, Cohn, Ferris, Glovsky and Popeo, P.C.

Primary Examiner:

Traviss C McIntosh, III

Int. Cl.
CPC ...
A61K 31/706 (2006.01); A61K 31/7056 (2006.01); A61K 31/685 (2006.01); A61K 31/53 (2006.01); C07H 1/00 (2006.01); C07H 1/02 (2006.01); C07H 11/00 (2006.01); C07H 15/18 (2006.01); A61K 31/6615 (2006.01); A61K 31/665 (2006.01); A61K 31/683 (2006.01); C07D 487/04 (2006.01); C07D 519/00 (2006.01); C07F 9/24 (2006.01); C07F 9/6561 (2006.01); A61K 31/675 (2006.01); A61K 45/06 (2006.01); A61K 31/00 (2006.01);
U.S. Cl.
CPC ...
A61K 31/685 (2013.01); A61K 31/00 (2013.01); A61K 31/53 (2013.01); A61K 31/665 (2013.01); A61K 31/6615 (2013.01); A61K 31/675 (2013.01); A61K 31/683 (2013.01); A61K 31/706 (2013.01); A61K 31/7056 (2013.01); A61K 45/06 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01); C07F 9/2429 (2013.01); C07F 9/65616 (2013.01); C07H 1/00 (2013.01); C07H 1/02 (2013.01); C07H 11/00 (2013.01); C07H 15/18 (2013.01);
Abstract

Provided are compounds, methods, and pharmaceutical compositions for treating Filoviridae virus infections by administering ribosides, riboside phosphates and prodrugs thereof, of Formula IV: The compounds, compositions, and methods provided are particularly useful for the treatment of Marburg virus, Ebola virus and Cueva virus infections.

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