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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10695347 B1

PDFFull Text
Date of Patent:
Jun. 30, 2020

Filed:

Nov. 04, 2016

Pyrimidine derivative and use thereof

Applicants:

Hubei Bio-pharmaceutical Industrial Technological Institute Inc., Wuhan, CN;

Humanwell Healthcare (Group) Co., Ltd., Wuhan, CN;

Inventors:

Xuehai Wang, Wuhan, CN;

Yong Xu, Wuhan, CN;

Xijun Sheng, Wuhan, CN;

Xiaolin Zhang, Wuhan, CN;

Hangui Xia, Wuhan, CN;

Zhongwen Yang, Wuhan, CN;

Yang Yue, Wuhan, CN;

Lu Huang, Wuhan, CN;

Qiang Xiao, Wuhan, CN;

Assignee:

HUBEI BIO-PHARMACEUTICAL INDUSTRIAL TECHNOLOGICAL INSTITUTE, INC., Wuhan, CN;

Attorneys:

Westman, Champliln & Koehler, P.A.

Z. Peter Sawicki

Amanda M. Prose

Primary Examiner:

Matthew P Coughlin

Int. Cl.
CPC ...
C07D 401/12 (2006.01); C07D 401/14 (2006.01); A61K 31/506 (2006.01); A61K 31/5377 (2006.01); C07D 409/14 (2006.01); C07D 239/48 (2006.01); C07D 409/12 (2006.01); C07D 413/14 (2006.01); A61P 35/00 (2006.01); A61K 45/06 (2006.01); A61K 9/00 (2006.01); A61K 9/08 (2006.01); A61K 9/12 (2006.01); A61K 9/14 (2006.01); A61K 9/20 (2006.01); A61K 9/48 (2006.01);
U.S. Cl.
CPC ...
A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61P 35/00 (2018.01); C07D 239/48 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 409/12 (2013.01); C07D 409/14 (2013.01); C07D 413/14 (2013.01); A61K 9/0019 (2013.01); A61K 9/08 (2013.01); A61K 9/12 (2013.01); A61K 9/14 (2013.01); A61K 9/20 (2013.01); A61K 9/48 (2013.01); A61K 2300/00 (2013.01);
Abstract

The present invention provides a pyrimidine derivative and a use thereof. The pyrimidine derivative is the compound shown in formula I or a pharmaceutically acceptable salt, hydrate, solvate, metabolite or prodrug thereof, wherein, R, R, R, Rand Rare, for example, as defined in the specification. The compound can act as an ALK inhibitor, and is for preparing an anti-tumor medicament for suppressing an anaplastic lymphoma kinase.

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