The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2020
Filed:
Feb. 03, 2017
Applicants:
The Johns Hopkins University, Baltimore, MD (US);
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, CN;
Inventors:
Jun Liu, Baltimore, MD (US);
Qingli He, Baltimore, MD (US);
Martin G. Pomper, Baltimore, MD (US);
Il Minn, Baltimore, MD (US);
Biao Yu, Baltimore, MD (US);
Qiaoling Wang, Baltimore, MD (US);
Assignees:
The Johns Hopkins University, Baltimore, MD (US);
Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai, CN;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01N 43/04 (2006.01); A61K 31/70 (2006.01); A61K 31/365 (2006.01); C07D 493/22 (2006.01); C07J 73/00 (2006.01); A61K 47/54 (2017.01); A61P 35/00 (2006.01); C07H 15/26 (2006.01);
U.S. Cl.
CPC ...
A61K 31/365 (2013.01); A61K 47/549 (2017.08); A61P 35/00 (2018.01); C07D 493/22 (2013.01); C07H 15/26 (2013.01); C07J 73/003 (2013.01);
Abstract
Provided are compounds generated by conjugation of triptolide with glucose to form glucose-triptolide conjugates, provides compounds with effective anti-proliferative activity and improved tolerability as compared to naturally occurring triptolide compounds.