The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 30, 2020

Filed:

Mar. 03, 2014
Applicant:

Besins Healthcare Luxembourg Sarl, Luxembourg, LU;

Inventors:

Maynard Emanuel Lichty, Durham, NC (US);

Garry T. Gwozdz, Jim Thorpe, PA (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 9/16 (2006.01); A61K 9/14 (2006.01); A61K 31/57 (2006.01); A61K 9/00 (2006.01);
U.S. Cl.
CPC ...
A61K 9/1652 (2013.01); A61K 9/0034 (2013.01); A61K 9/0043 (2013.01); A61K 9/14 (2013.01); A61K 9/1682 (2013.01); A61K 31/57 (2013.01);
Abstract

Provided herein are dry pharmaceutical compositions for transmucosal delivery, comprising spray-dried particles that include pharmaceutically active agent nanoparticles, a binder, and a pharmaceutically acceptable carrier, where the active agent nanoparticles have an average particle size diameter prior to spray-drying of less than about 1 μm, and wherein up to 10% of the spray-dried particles have a particle size of less than 10 μm; at least 50% of the spray-dried particles have a particle size of at least about 15 μm; and at least 90% of the spray-dried particles have a particle size of up to about 55 μm. Also provided are methods for making such pharmaceutical compositions and therapeutic methods comprising transmucosally administering the compositions, such as intranasally or intravaginally.


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