The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 30, 2020
Filed:
Nov. 30, 2015
Applicant:
Magyar Tudományos Akadémia Kísérleti Orvostudományi Kutató Intézet, Budapest, HU;
Inventors:
Csaba Fekete, Budapest, HU;
Balázs Gereben, Budapest, HU;
Petra Mohácsik, Budapest, HU;
Ferenc Erdélyi, Budapest, HU;
Gábor Szabó, Budapest, HU;
Assignee:
Kisérleti Orvostudoányi Kutatóintézet, Budapest, HU;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A01K 67/027 (2006.01); C12N 15/00 (2006.01); C12N 15/63 (2006.01); C07H 21/04 (2006.01); C12N 15/85 (2006.01); A61K 49/00 (2006.01); C12Q 1/6897 (2018.01); G01N 33/50 (2006.01); G01N 33/78 (2006.01);
U.S. Cl.
CPC ...
A01K 67/0275 (2013.01); A61K 49/0008 (2013.01); C12N 15/85 (2013.01); C12N 15/8509 (2013.01); C12Q 1/6897 (2013.01); G01N 33/5088 (2013.01); G01N 33/78 (2013.01); A01K 2217/052 (2013.01); A01K 2217/07 (2013.01); A01K 2217/20 (2013.01); A01K 2217/203 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0393 (2013.01); C07H 21/04 (2013.01); C12N 2015/859 (2013.01); C12N 2800/90 (2013.01); C12N 2830/002 (2013.01);
Abstract
A transgenic animal model that is suitable for the cell or tissue specific assessing of thyroid hormone (TH) action in vivo is described. The recombinant DNA construct and methods suitable to generate such an animal are also provided. The assessment of TH action is based on a reporter that is dependent on an endogenously expressed thyroid hormone receptor (TR) and coregulators of said receptor.