The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2020
Filed:
Sep. 25, 2015
Applicant:
National University of Singapore, Singapore, SG;
Inventors:
Fu Xin-Yuan, Singapore, SG;
Wanqiang Sheng, Singapore, SG;
Yongliang Zhang, Singapore, SG;
Fan Yang, Singapore, SG;
Assignee:
NATIONAL UNIVERSITY OF SINGAPORE, Singapore, SG;
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
G01N 33/564 (2006.01); C12Q 1/6883 (2018.01); C12N 5/0783 (2010.01); A61K 39/00 (2006.01); A61K 31/4433 (2006.01); G01N 33/68 (2006.01);
U.S. Cl.
CPC ...
G01N 33/564 (2013.01); A61K 31/4433 (2013.01); A61K 39/0008 (2013.01); C12N 5/0636 (2013.01); C12N 5/0637 (2013.01); C12Q 1/6883 (2013.01); G01N 33/6863 (2013.01); G01N 33/6869 (2013.01); C12N 2501/2307 (2013.01); C12N 2501/24 (2013.01); C12N 2501/51 (2013.01); C12N 2501/515 (2013.01); C12N 2501/60 (2013.01); C12N 2501/727 (2013.01); C12Q 2600/118 (2013.01); C12Q 2600/158 (2013.01); G01N 2333/4706 (2013.01); G01N 2333/535 (2013.01); G01N 2333/5403 (2013.01); G01N 2333/5418 (2013.01); G01N 2800/102 (2013.01); G01N 2800/285 (2013.01);
Abstract
Disclosed herein is a T-helper cell ('T-GM' cell) that is regulated by IL-7/STAT5 and which secrete GM-CSF/IL-3. Also disclosed are methods and compositions for modulating T-GM function for the treatment of, e.g., inflammatory disorders. Diagnostic and prognostic methods for specifically identifying T-GM-mediated inflammatory disorders (e.g., rheumatoid arthritis), as distinct from and/or in addition to non-T-GM-mediated (e.g., TNF-α-mediated) inflammatory disorders, are also provided.