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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10690619 B1

PDFFull Text
Date of Patent:
Jun. 23, 2020

Filed:

Dec. 08, 2014

Apparatus and method for measuring concentration of an analyte in whole blood samples

Applicant:

I-sens, Inc., Seoul, KR;

Inventors:

Geun Sig Cha, Seoul, KR;

Hakhyun Nam, Seoul, KR;

Seok-Won Lee, Seongnam-si, KR;

Sung Hyuk Choi, Gwacheon-si, KR;

Youngjea Kang, Seoul, KR;

Myeongho Lee, Seoul, KR;

Ho Dong Park, Wonju-si, KR;

Sung Pil Cho, Wonju-si, KR;

Assignee:

I-SENS, INC., Seoul, KR;

Attorney:

Morgan, Lewis & Bockius LLP

Primary Examiner:

Michael Y Sun

Int. Cl.
CPC ...
G01N 27/327 (2006.01); G01N 33/49 (2006.01); G01N 33/487 (2006.01); C12Q 1/00 (2006.01); G01N 33/543 (2006.01); A61B 5/1468 (2006.01); G01N 33/53 (2006.01); B01L 3/00 (2006.01); A61B 5/1495 (2006.01); A61B 5/145 (2006.01); G01N 27/49 (2006.01); G01N 33/26 (2006.01); G01N 33/52 (2006.01); G01N 27/48 (2006.01); G01N 27/42 (2006.01);
U.S. Cl.
CPC ...
G01N 27/3274 (2013.01); G01N 27/3272 (2013.01); G01N 33/48707 (2013.01); G01N 33/49 (2013.01); A61B 5/1468 (2013.01); A61B 5/1495 (2013.01); A61B 5/14532 (2013.01); A61B 2562/0295 (2013.01); B01L 3/5023 (2013.01); B01L 2200/16 (2013.01); B01L 2300/0645 (2013.01); B01L 2300/0825 (2013.01); C12Q 1/001 (2013.01); C12Q 1/002 (2013.01); G01N 27/3271 (2013.01); G01N 27/3273 (2013.01); G01N 27/3277 (2013.01); G01N 27/42 (2013.01); G01N 27/48 (2013.01); G01N 27/49 (2013.01); G01N 33/26 (2013.01); G01N 33/4875 (2013.01); G01N 33/48771 (2013.01); G01N 33/52 (2013.01); G01N 33/5302 (2013.01); G01N 33/5438 (2013.01);
Abstract

A method for measuring a concentration of an analyte in a bio-sample using an electrochemical bio-sensor according to an exemplary embodiment of the present invention is characterized by a step of obtaining predetermined features from induced currents obtained by applying a DC voltage according to chronoamperometry in which, after a whole blood sample is injected to the electrochemical bio-sensor, a concentration of an analyte is obtained from an induced current obtained by applying a DC voltage for a certain time and from all induced currents obtained by further applying several step-ladder perturbation potentials for a short time subsequent to the DC voltage for the certain time, and is also characterized by minimization of a measurement error caused by a hindering material by forming a calibration equation by combining the at least one feature in a function and optimizing various conditions of the bio-sample through DeletedTextsmultivariable analysis. With this configuration, a perturbation potential application method added to a conventional measurement method can maintain a bio-sensor and a measuring apparatus already used, a line used in the measuring apparatus, and calibration of amperometry as they are, improve accuracy in measurement by effectively minimizing a matrix interference effect of a background material in a bio-sample, particularly an inaccuracy caused by a change in hematocrit, and also remarkably improve accuracy in measurement by simply upgrading a measurement program of a conventional measuring apparatus.

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