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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10689681 B1

PDFFull Text
Date of Patent:
Jun. 23, 2020

Filed:

Jun. 02, 2014

Microorganisms for diterpene production

Applicant:

Dsm Ip Assets B.v., Heerlen, NL;

Inventors:

Viktor Marius Boer, Echt, NL;

Erwin Suir, Echt, NL;

Assignee:

DSM IP ASSETS B.V., Heerlen, NL;

Attorney:

McBee Moore & Vanik IP, LLC

Primary Examiner:

Hope A Robinson

Int. Cl.
CPC ...
C12P 19/56 (2006.01); C12N 9/88 (2006.01); C12N 9/02 (2006.01); C12N 9/16 (2006.01); C12N 15/52 (2006.01); C12N 9/90 (2006.01); C07K 14/39 (2006.01); C12N 9/10 (2006.01); C12N 9/24 (2006.01); A23L 27/30 (2016.01); A23L 2/60 (2006.01); C07K 14/395 (2006.01); C12P 15/00 (2006.01); C07H 15/256 (2006.01);
U.S. Cl.
CPC ...
C12P 19/56 (2013.01); A23L 2/60 (2013.01); A23L 27/36 (2016.08); C07H 15/256 (2013.01); C07K 14/39 (2013.01); C07K 14/395 (2013.01); C12N 9/0036 (2013.01); C12N 9/0042 (2013.01); C12N 9/0073 (2013.01); C12N 9/0083 (2013.01); C12N 9/1051 (2013.01); C12N 9/16 (2013.01); C12N 9/2405 (2013.01); C12N 9/88 (2013.01); C12N 9/90 (2013.01); C12N 15/52 (2013.01); C12P 15/00 (2013.01); A23V 2002/00 (2013.01);
Abstract

The present invention relates to a recombinant microorganism comprising one or more nucleotide sequence(s) encoding: a polypeptide having ent-copalyl pyrophosphate synthase activity; a polypeptide having ent-Kaurene synthase activity; a polypeptide having ent-Kaurene oxidase activity; and a polypeptide having kaurenoic acid 13-hydroxylase activity, whereby expression of the nucleotide sequence(s) confer(s) on the microorganism the ability to produce at least steviol. The recombinant microorganism may also be capable of expressing one or more UDP-glucosyltransferases such that the microorganism is capable of producing one or more steviol glycosides.

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