The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2020
Filed:
Feb. 01, 2018
Applicant:
Abbvie Inc., North Chicago, IL (US);
Inventors:
Michael J. Abrahamson, Chicago, IL (US);
Sanjay R. Chemburkar, Gurnee, IL (US);
Angelica B. Kielbus, Evanston, IL (US);
Russell D. Cink, Grayslake, IL (US);
Assignee:
AbbVie Inc., North Chicago, IL (US);
Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C12P 7/62 (2006.01); C12P 7/40 (2006.01); C12N 9/18 (2006.01); C07C 67/343 (2006.01);
U.S. Cl.
CPC ...
C12P 7/62 (2013.01); C07C 67/343 (2013.01); C12N 9/18 (2013.01); C12Y 301/01001 (2013.01); C12Y 304/21014 (2013.01);
Abstract
Disclosed are methods of synthesizing racemic 2-(difluoromethyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and 2-(vinyl)-1-(alkoxycarbonyl)-cyclopropanecarboxylic acids and their salts, such as the dicyclohexylamine salt. Also disclosed are methods for preparing enantioenriched (1R,2R)-1-((tert-butoxycarbonyl)amino)-2-(difluoromethyl)cyclopropane-1-carboxylic acid and esters of the same. These compounds are useful intermediates in the synthesis of viral protease inhibitors.