The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2020
Filed:
Nov. 14, 2014
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Hiroshi Iwata, Brookline, MA (US);
Masanori Aikawa, Chestnut Hill, MA (US);
Takuya Hara, Fuji, JP;
Sasha Singh, Boston, MA (US);
Piero Ricchiuto, Milan, IT;
Hideo Yoshida, Brookline, MA (US);
Iwao Yamada, Boston, MA (US);
The Brigham and Women's Hospital, Inc., Boston, MA (US);
Abstract
The invention relates to compositions and methods for inhibiting macrophage activation via modulating PARP9 and/or PARP14 expression or activity, such as small molecules, RNAi and antibodies. Modulating the expression and/or activity of PARP9 and/or PARP14 allows the inhibition of monocytes or macrophage M1 activation and inflammation. Inhibiting undesirable excessive or sustained inflammation found in humans, for the treatment, prevention and/or management of conditions where undesirable excessive or sustained inflammation is known or likely to contribute to the onset, development and/or progression the conditions.