The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2020
Filed:
Mar. 05, 2018
Applicant:
Brandeis University, Waltham, MA (US);
Inventors:
Jeffrey N. Agar, Newton, MA (US);
Joseph Salisbury, Cranston, RI (US);
Assignee:
Brandeis University, Waltham, MA (US);
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/96 (2006.01); C12N 9/02 (2006.01); A61K 31/095 (2006.01); A61K 31/385 (2006.01); C07K 19/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/96 (2013.01); A61K 31/095 (2013.01); A61K 31/385 (2013.01); C07K 19/00 (2013.01); C12N 9/0089 (2013.01); C12Y 115/01001 (2013.01); C07K 2319/00 (2013.01);
Abstract
Described herein are compounds and methods for tethering proteins. For example, dimers of proteins, including SOD1 and DJ-1, are described, where the dimers are formed by the covalent bonding of a cysteine on the first monomer to a cysteine on the second monomer via a cyclic disulfide linker. The covalently attached dimers exhibit increased stabilization.