The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2020
Filed:
Apr. 09, 2018
Applicant:
Adaptimmune Limited, Abingdon, Oxfordshire, GB;
Inventors:
Bruno Laugel, Abingdon, GB;
Kathrin Skibbe, Abingdon, GB;
Assignee:
ADAPTIMMUNE LIMITED, Abingdon, Oxfordshire, GB;
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/0783 (2010.01); C12N 9/16 (2006.01); A61K 39/00 (2006.01); A61K 35/17 (2015.01); C07K 14/725 (2006.01); C12N 15/86 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0638 (2013.01); A61K 35/17 (2013.01); A61K 39/0011 (2013.01); C07K 14/7051 (2013.01); C12N 5/0636 (2013.01); C12N 9/16 (2013.01); C12N 15/86 (2013.01); C12Y 301/04053 (2013.01); A61K 2039/5156 (2013.01); A61K 2039/5158 (2013.01); C12N 2501/01 (2013.01); C12N 2510/00 (2013.01); C12N 2740/15043 (2013.01);
Abstract
This invention relates to the treatment of cancer in an individual by administration of a population of modified T cells that express a recombinant cAMP phosphodiesterase (PDE) or a fragment thereof and an antigen receptor which binds specifically to cancer cells in the individual. Populations of modified T cells and methods of producing populations of modified T cells are provided, along with pharmaceutical compositions and methods of treatment.