The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 23, 2020
Filed:
Sep. 13, 2016
Brightgene Bio-medical Technology Co., Ltd., Suzhou, Jiangsu, CN;
Jiandong Yuan, Suzhou, CN;
Yangqing Huang, Suzhou, CN;
Linfeng Miao, Suzhou, CN;
Jianing Gu, Suzhou, CN;
Chaohua Liang, Suzhou, CN;
Zhengye Wang, Suzhou, CN;
Zhanli Sun, Suzhou, CN;
BrightGene Bio-Medical Technology Co., Ltd., Jiangsu, CN;
Abstract
Provided is a preparation method of a composition enriched in compound S-1. The method performs isomer separation on a reaction product from the first step, and then performs a two-step chemical synthesis, so as to prepare a composition comprising high-purity compound S-1, wherein the HPLC purity of the single isomer S-1 is 90% or more. Provided is a composition enriched in compound S-1. The composition has an inhibitory effect on tumor cell proliferation in vitro significantly higher than that of NUC-1031 and compound R-1. Also provided are the use of the composition, and a pharmaceutical composition comprising the composition and at least one pharmaceutically acceptable excipient.