The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 23, 2020

Filed:

Nov. 03, 2017
Applicant:

Amgen Inc., Thousand Oaks, CA (US);

Inventors:

Yinhong Chen, Hayward, CA (US);

Alan C. Cheng, San Francisco, CA (US);

Mikkel V. Debenedetto, Waltham, MA (US);

Paul John Dransfield, Arlington, MA (US);

James S. Harvey, Arlington, MA (US);

Jonathan Houze, Cambridge, MA (US);

Aarif Yusuf Khakoo, Woodside, CA (US);

Su-Jen Lai, Cambridge, MA (US);

Zhihua Ma, Lexington, MA (US);

Vatee Pattaropong, Bedford, MA (US);

Gayathri Swaminath, Brisbane, CA (US);

Charles Kreiman, Hopkinton, MA (US);

David C. Moebius, Westwood, MA (US);

Ankit Sharma, Quincy, MA (US);

Assignee:

AMGEN INC., Thousand Oaks, CA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/14 (2006.01); C07D 405/14 (2006.01); C07D 413/14 (2006.01); A61P 9/04 (2006.01); C07D 417/14 (2006.01); A61K 45/06 (2006.01); C07D 401/12 (2006.01);
U.S. Cl.
CPC ...
C07D 401/14 (2013.01); A61P 9/04 (2018.01); C07D 401/12 (2013.01); C07D 405/14 (2013.01); C07D 413/14 (2013.01); C07D 417/14 (2013.01); A61K 45/06 (2013.01);
Abstract

Compounds of Formula I and Formula II, pharmaceutically acceptable salt thereof, stereoisomers of any of the foregoing, or mixtures thereof are agonists of the APJ Receptor and may have use in treating cardiovascular and other conditions. Compounds of Formula I and Formula II have the structures where the definitions of the variables are provided herein.


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