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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10689335 B1

PDFFull Text
Date of Patent:
Jun. 23, 2020

Filed:

Apr. 04, 2016

Hydrogen sulfide precursors and conjugates thereof

Applicant:

Georgia State University Research Foundation, Inc., Atlanta, GA (US);

Inventors:

Binghe Wang, Marietta, GA (US);

Yueqin Zheng, Atlanta, GA (US);

Kaili Ji, Brookhaven, GA (US);

Bingchen Yu, Atlanta, GA (US);

Zhixiang Pan, Brookhaven, GA (US);

Assignee:

Georgia State University Research Foundation, Inc., Atlanta, GA (US);

Attorney:

Kilpatrick Townsend & Stockton LLP

Primary Examiner:

Umamaheswari Ramachandran

Int. Cl.
CPC ...
C07C 327/12 (2006.01); C07C 381/00 (2006.01); C07F 9/12 (2006.01); C01B 17/16 (2006.01); A61P 15/10 (2006.01); A61P 27/02 (2006.01); A61P 37/00 (2006.01); A61P 7/02 (2006.01); A61P 13/08 (2006.01); A61P 3/08 (2006.01); A61P 9/10 (2006.01); A61P 25/28 (2006.01); A61P 9/00 (2006.01); A61P 11/06 (2006.01); A61P 19/02 (2006.01); A61P 9/12 (2006.01); A61P 13/02 (2006.01); A61P 13/12 (2006.01); A61P 1/00 (2006.01); A61P 11/00 (2006.01); A61P 25/00 (2006.01); A61P 25/16 (2006.01); A61P 29/00 (2006.01); A61P 35/00 (2006.01); C07C 323/62 (2006.01); C12P 3/00 (2006.01);
U.S. Cl.
CPC ...
C07C 327/12 (2013.01); A61P 1/00 (2018.01); A61P 3/08 (2018.01); A61P 7/02 (2018.01); A61P 9/00 (2018.01); A61P 9/10 (2018.01); A61P 9/12 (2018.01); A61P 11/00 (2018.01); A61P 11/06 (2018.01); A61P 13/02 (2018.01); A61P 13/08 (2018.01); A61P 13/12 (2018.01); A61P 15/10 (2018.01); A61P 19/02 (2018.01); A61P 25/00 (2018.01); A61P 25/16 (2018.01); A61P 25/28 (2018.01); A61P 27/02 (2018.01); A61P 29/00 (2018.01); A61P 35/00 (2018.01); A61P 37/00 (2018.01); C01B 17/16 (2013.01); C07C 323/62 (2013.01); C07C 381/00 (2013.01); C07F 9/12 (2013.01); C12P 3/00 (2013.01); C07C 2601/02 (2017.05); C07C 2602/08 (2017.05);
Abstract

The present invention provides methods of forming hydrogen sulfide. The methods include contacting a precursor compound with an unmasking agent; wherein the precursor compound comprises a hydrogen sulfide releasing moiety and a masked nucleophile; and wherein the contacting is conducted under conditions sufficient for cyclization of the precursor compound via lactone or lactam formation; thereby releasing hydrogen sulfide from the precursor compound. Hydrogen sulfide precursor compounds according to Formula I are also described, as well as methods for treating diseases and conditions using hydrogen sulfide precursors.

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