The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 23, 2020

Filed:

Jul. 15, 2019
Applicant:

Taisho Pharmaceuticals Co., Ltd., Tokyo, JP;

Inventors:

Norikazu Otake, Tokyo, JP;

Takashi Hashihayata, Tokyo, JP;

Yohei Matsuda, Tokyo, JP;

Seiji Masuda, Tokyo, JP;

Yuko Yamauchi, Tokyo, JP;

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07C 229/50 (2006.01); C07D 213/61 (2006.01); C07D 213/64 (2006.01); C07C 271/24 (2006.01); C07C 255/47 (2006.01);
U.S. Cl.
CPC ...
C07C 229/50 (2013.01); C07C 255/47 (2013.01); C07C 271/24 (2013.01); C07D 213/61 (2013.01); C07D 213/64 (2013.01); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2601/16 (2017.05); C07C 2602/18 (2017.05); C07C 2602/42 (2017.05); C07C 2602/48 (2017.05); C07C 2603/56 (2017.05); C07C 2603/74 (2017.05);
Abstract

Provided is an amino acid derivative prodrug represented by general formula (I-A) that is a prodrug form of an amino acid derivative which is a group 2 metabotropic glutamate receptor antagonist, or a pharmaceutically acceptable salt thereof. More specifically, provided is an amino acid derivative prodrug represented by general formula (I-A) that is a preventive or therapeutic drug for mood disorders (including depression and bipolar disorder), anxiety disorder, cognitive disorders, developmental disorders, Alzheimer's disease, Parkinson's disease, movement disorders associated with muscular rigidity, sleep disorders, Huntington's chorea, eating disorders, drug dependence, epilepsy, brain infarction, cerebral ischemia, cerebral insufficiency, cerebral edema, spinal cord disorders, head trauma, inflammation and immune-related diseases, and so on.


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