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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10688193 B1

PDFFull Text
Date of Patent:
Jun. 23, 2020

Filed:

Jul. 21, 2016

Ph-sensitive linkers for delivering a therapeutic agent

Applicant:

Gnt Biotech & Medicals Corporation, Taipei, TW;

Inventors:

Yu-Jung Liao, Taipei, TW;

Wei-Jan Huang, Taipei, TW;

Chia-Nan Chen, Taipei, TW;

Huan-Yu Lin, Taipei, TW;

Ching-Yi Lin, Taipei, TW;

Meng-Ju Tsai, Taipei, TW;

Wan-Yi Hsu, Taipei, TW;

Li-Ling Chi, Taipei, TW;

Ye-Su Chao, Taipei, TW;

Yi-Hong Wu, Taipei, TW;

Assignee:

GNT BIOTECH & MEDICALS CORPORATION, Taipei, TW;

Attorney:

Duane Morris

Primary Examiner:

Ana Z Muresan

Int. Cl.
CPC ...
A61K 47/64 (2017.01); A61K 47/60 (2017.01); A61K 47/69 (2017.01); C07C 243/26 (2006.01); C07C 271/22 (2006.01); C07C 323/60 (2006.01); C07K 5/062 (2006.01); A61K 9/14 (2006.01); C07C 323/52 (2006.01); C07D 339/04 (2006.01); C07K 5/103 (2006.01); A61P 35/00 (2006.01); A61K 47/20 (2006.01); A61K 31/351 (2006.01); A61K 31/437 (2006.01); A61K 33/24 (2019.01); A61K 47/22 (2006.01);
U.S. Cl.
CPC ...
A61K 47/64 (2017.08); A61K 9/143 (2013.01); A61K 47/20 (2013.01); A61K 47/60 (2017.08); A61K 47/6923 (2017.08); A61K 47/6929 (2017.08); A61P 35/00 (2018.01); C07C 243/26 (2013.01); C07C 271/22 (2013.01); C07C 323/52 (2013.01); C07C 323/60 (2013.01); C07D 339/04 (2013.01); C07K 5/06026 (2013.01); C07K 5/1008 (2013.01); A61K 31/351 (2013.01); A61K 31/437 (2013.01); A61K 33/24 (2013.01); A61K 47/22 (2013.01); A61K 2300/00 (2013.01);
Abstract

The invention provides a pH-sensitive linker that can simultaneously bind metallic nanoparticles and one or more agents with various molecular size. The linker of the invention can deliver the agents into cells involved in disease processes or close to cells so that the agents can selectively target and effect on the cells. The target delivery provided by the linker of the invention can be used for example for disease sensing, imaging, drug delivery, and therapy.

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