The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Jan. 12, 2017
Applicants:
The George Washington University, a Congressionally Chartered Not-for-profit Corporation, Washington, DC (US);
Alexei Adzhubei, Moscow, RU;
Inventors:
Alexei Adzhubei, Moscow, RU;
Michael Bukrinsky, Potomac, MD (US);
Ruth Hunegnaw, Arlington, VA (US);
Assignee:
THE GEORGE WASHINGTON UNIVERSITY, A CONGRESSIONLLY CHARTERED NOT-FOR-PROFIT CORPORATION, Washington, DC (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
G01N 33/50 (2006.01); C07C 223/06 (2006.01); C07D 209/56 (2006.01); C07C 381/00 (2006.01); A61K 31/18 (2006.01); A61K 31/167 (2006.01); A61K 31/404 (2006.01);
U.S. Cl.
CPC ...
G01N 33/5041 (2013.01); A61K 31/167 (2013.01); A61K 31/18 (2013.01); A61K 31/404 (2013.01); C07C 223/06 (2013.01); C07C 381/00 (2013.01); C07D 209/56 (2013.01); G01N 33/502 (2013.01); G01N 2333/163 (2013.01); G01N 2333/4727 (2013.01); G01N 2500/02 (2013.01);
Abstract
The invention relates to compounds and methods for restoring or preserving cholesterol efflux in a cell infected with Human Immunodeficiency Virus (HIV) by preventing or decreasing an interaction between Negative Regulatory Factor (Nef) protein and Calnexin protein, and methods for screening for such compounds.