The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Apr. 08, 2016
Applicant:
The Methodist Hospital System, Houston, TX (US);
Inventor:
Youli Zu, Bellaire, TX (US);
Assignee:
Other;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); C12N 15/115 (2010.01); C07K 14/475 (2006.01); G01N 33/574 (2006.01);
U.S. Cl.
CPC ...
C12N 15/115 (2013.01); C07K 14/475 (2013.01); G01N 33/57407 (2013.01); C12N 2310/16 (2013.01); C12N 2310/351 (2013.01); G01N 2800/50 (2013.01);
Abstract
Disclosed are compositions and methods relating to nucleic acid aptamers that specifically target CD117 protein and also selective binding to CD117-expressing cells. The ligand-drug conjugates specifically target CD117-expressing cells and subsequently internalize into the cells, leading apoptosis, growth inhibition, and death of cells of interest and no off-target toxicity to CD117-negative normal cells.