The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 16, 2020

Filed:

May. 17, 2017
Applicants:

Consejo Superior DE Investigaciones Científicas, Madrid, ES;

Technical University of Darmstadt, Darmstadt, DE;

Sustainable Momentum, S.l., Las Palmas de Gran Canaria, ES;

Inventors:

Pedro Clapés Saborit, Barcelona, ES;

Karel Hernández Sánchez, Barcelona, ES;

Jesús Joglar Tamargo, Barcelona, ES;

Jordi Bujons Vilás, Barcelona, ES;

Wolf-Dieter Fessner, Darmstadt, DE;

Pablo Domínguez De María, Las Palmas de Gran Canaria, ES;

Assignees:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 9/88 (2006.01); C12N 15/52 (2006.01); C12N 15/62 (2006.01); C12N 15/85 (2006.01);
U.S. Cl.
CPC ...
C12N 9/88 (2013.01); C12N 15/52 (2013.01); C12N 15/62 (2013.01); C12N 15/85 (2013.01); C07K 2319/24 (2013.01); C12N 2015/8518 (2013.01); C12Y 401/02 (2013.01);
Abstract

The present invention refers to an enzyme consisting of a fusion protein particularly useful as shown through-out the present invention for carrying out the carbon-carbon bond-forming reaction known as the aldol Reaction, preferably for carrying out an aldol reaction by using aldehydes as substrates and preferably pyruvate or a salt thereof, for producing hydroxyketoacids. Said enzyme is made by binding an aldolase to a maltose binding protein. The enzymes display full activity under 'highly denaturing' substrate loadings (aldehydes, >1 M).


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