The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Mar. 05, 2019
Korea Research Institute of Chemical Technology, Daejeon, KR;
Jung-Hwa Oh, Daejeon, KR;
Jaehwan Ahn, Daejeon, KR;
Seokjoo Yoon, Daejeon, KR;
Heeyoung Yang, Daejeon, KR;
Jun-Ho Ahn, Daejeon, KR;
Mi-Sun Choi, Daejeon, KR;
Soojin Kim, Daejeon, KR;
Se-Myo Park, Daejeon, KR;
Hyoung-Yun Han, Daejeon, KR;
KOREA RESEARCH INSTITUTE OF CHEMICAL TECHNOLOGY, Daejeon, KR;
Abstract
A microfabricated platform for mimicking the liver zonation and an evaluating method of zone-specific hepatotoxicity using the same is provided. The microfabricated platform for mimicking the liver zonation prepared according to the method of the present invention is divided into three zones of zone 1, zone 2 and zone 3 similarly to in vivo liver tissue and thus the zone-specific hepatotoxicity of a drug in the liver can be evaluated using the same. According to the present invention, the zone-specific hepatotoxicity results can be analyzed quantitatively by using image analysis, so that the platform of the present invention can be effectively used for in vitro screening of zone-specific hepatotoxicity.