The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Sep. 23, 2016
Applicant:
Board of Regents, the University of Texas System, Austin, TX (US);
Inventors:
Joachim Herz, Austin, TX (US);
Yinyuan Ding, Austin, TX (US);
Xunde Xian, Austin, TX (US);
Linzhang Huang, Austin, TX (US);
Chieko Mineo, Austin, TX (US);
Philip Shaul, Austin, TX (US);
Laurent Calvier, Austin, TX (US);
Assignee:
BOARD OF REGENTS, THE UNIVERSITY OF TEXAS SYSTEM, Austin, TX (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/40 (2006.01); A61K 45/06 (2006.01); C12N 15/113 (2010.01); A01K 67/027 (2006.01); A61K 38/00 (2006.01); A61K 31/713 (2006.01); C07K 16/18 (2006.01); A61K 39/00 (2006.01); A61P 9/10 (2006.01);
U.S. Cl.
CPC ...
C07K 16/40 (2013.01); A01K 67/0276 (2013.01); A61K 31/713 (2013.01); A61K 38/00 (2013.01); A61K 45/06 (2013.01); C12N 15/1137 (2013.01); A01K 2217/075 (2013.01); A01K 2217/15 (2013.01); A01K 2217/206 (2013.01); A01K 2227/105 (2013.01); A01K 2267/0375 (2013.01); A61K 2039/505 (2013.01); A61P 9/10 (2018.01); C07K 16/18 (2013.01); C07K 2317/21 (2013.01); C07K 2317/24 (2013.01); C12N 15/1138 (2013.01); C12N 2310/14 (2013.01);
Abstract
The present invention provides methods and compositions for treating atherosclerosis in a subject comprising the use of therapeutic compounds to reduce Reelin in the circulation of the subject, thereby reducing the adhesion of leukocytes to the vascular wall. The invention also provides methods and compositions for reducing leukocyte adhesion to the vascular wall in a subject.