The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 16, 2020

Filed:

Mar. 08, 2017
Applicant:

Deep Science, Llc, Bellevue, WA (US);

Inventors:

Mahalaxmi Gita Bangera, Renton, WA (US);

Ed Harlow, Boston, MA (US);

Roderick A. Hyde, Redmond, WA (US);

Muriel Y. Ishikawa, Livermore, CA (US);

Edward K. Y. Jung, Bellevue, WA (US);

Eric C. Leuthardt, St. Louis, MO (US);

Nathan P. Myhrvold, Medina, WA (US);

Dennis J. Rivet, Richmond, VA (US);

Elizabeth A. Sweeney, Seattle, WA (US);

Clarence T. Tegreene, Mercer Island, WA (US);

Lowell L. Wood, Jr., Bellevue, WA (US);

Victoria Y. H. Wood, Livermore, CA (US);

Assignee:

DEEP SCIENCE, LLC, Bellevue, WA (US);

Attorneys:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
C01B 32/158 (2017.01); C01B 32/174 (2017.01); C07K 16/32 (2006.01); B82Y 30/00 (2011.01); B82Y 40/00 (2011.01); A61K 47/69 (2017.01); C01B 32/168 (2017.01); A61K 47/68 (2017.01); A61K 47/60 (2017.01); A61K 38/17 (2006.01); C01B 21/064 (2006.01); B82Y 5/00 (2011.01); B82Y 15/00 (2011.01);
U.S. Cl.
CPC ...
C07K 16/32 (2013.01); A61K 38/1703 (2013.01); A61K 38/1732 (2013.01); A61K 47/60 (2017.08); A61K 47/6871 (2017.08); A61K 47/6901 (2017.08); B82Y 30/00 (2013.01); B82Y 40/00 (2013.01); C01B 21/0648 (2013.01); C01B 32/168 (2017.08); C01B 32/174 (2017.08); B82Y 5/00 (2013.01); B82Y 15/00 (2013.01); C01B 2202/02 (2013.01); C01B 2202/34 (2013.01); C01B 2202/36 (2013.01); C01P 2004/13 (2013.01); Y02A 50/473 (2018.01); Y10S 977/743 (2013.01); Y10S 977/75 (2013.01); Y10S 977/762 (2013.01); Y10S 977/788 (2013.01); Y10S 977/795 (2013.01); Y10S 977/848 (2013.01); Y10S 977/896 (2013.01); Y10S 977/915 (2013.01);
Abstract

Devices, compositions, and methods are described which provide a tubular nanostructure or a composite tubular nanostructure targeted to a lipid bilayer membrane. The tubular nanostructure includes a hydrophobic surface region flanked by two hydrophilic surface regions. The tubular nanostructure is configured to interact with a lipid bilayer membrane and form a pore in the lipid bilayer membrane. The tubular nanostructure may be targeted by including at least one ligand configured to bind to one or more cognates on the lipid bilayer membrane of a target cell.


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