The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Jan. 30, 2019
Applicant:
Flagship Pioneering Innovations V, Inc., Cambridge, MA (US);
Inventors:
Avak Kahvejian, Lexington, MA (US);
Jordi Mata-Fink, Baltimore, MD (US);
Jonathan Barry Hurov, Bedford, MA (US);
Chengyi Jenny Shu, Cambridge, MA (US);
George Huck Neubauer, Malden, MA (US);
Julian Alexander Stanley, Oregon City, OR (US);
Assignee:
Flagship Pioneering Innovations V, Inc., Cambridge, MA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 16/28 (2006.01); A61K 31/7105 (2006.01); A61K 31/4188 (2006.01); A61K 38/16 (2006.01); A61K 9/00 (2006.01); A61P 35/04 (2006.01); G01N 33/50 (2006.01); A61K 31/137 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07K 16/286 (2013.01); A61K 9/0019 (2013.01); A61K 9/0053 (2013.01); A61K 31/137 (2013.01); A61K 31/4188 (2013.01); A61K 31/7105 (2013.01); A61K 38/164 (2013.01); A61P 35/04 (2018.01); G01N 33/5011 (2013.01); A61K 45/06 (2013.01);
Abstract
The present invention provides methods for treating cancer using mGluR8 inhibitors, such as mGluR8 inhibitory antibodies and small molecules. The invention also features compositions containing mGluR8 inhibitors, methods of diagnosing patients with mGluR8-associated cancer, and methods of predicting the response of cancer in a subject to treatment with mGluR8 inhibitors.