The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Nov. 29, 2013
Applicant:
Max-delbrueck-centrum Fuer Molekulare Medizin (Mdc) Berlin-buch, Berlin, DE;
Inventors:
Thomas Blankenstein, Berlin, DE;
Gerald Willimsky, Berlin, DE;
Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07K 14/725 (2006.01); C07K 14/47 (2006.01); A61K 39/00 (2006.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 14/7051 (2013.01); A61K 39/0011 (2013.01); C07K 14/4748 (2013.01); A61K 38/00 (2013.01);
Abstract
The present invention relates to a method for the production of novel T-cell receptors (TCR) which provide a reduced risk of adverse events in immune therapy, specifically in adoptive T cell transfer. The TCRs produced according to the method of the invention are specific for tumor cells and do not react with healthy tissue. Furthermore provided are nucleic acids encoding the TCR of the invention, vectors and host cells comprising the TCRs of the invention as well as their use is the treatment of tumorous diseases.