The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
May. 31, 2017
Applicant:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Inventors:
Richard D. Dimarchi, Carmel, IN (US);
John P. Mayer, Indianapolis, IN (US);
Piotr Mroz, Bloomington, IN (US);
Assignee:
Indiana University Research and Technology Corporation, Indianapolis, IN (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/26 (2006.01); C07K 14/605 (2006.01); A61K 38/28 (2006.01); A61P 3/10 (2006.01);
U.S. Cl.
CPC ...
C07K 14/605 (2013.01); A61K 38/26 (2013.01); A61K 38/28 (2013.01); A61P 3/10 (2018.01);
Abstract
Modified glucagon peptides are disclosed having improved solubility and/or stability while retaining glucagon agonist activity. The glucagon peptides have been modified by the substitution of pyridyl-alanine for a native amino acid at one or more of positions 6, 10 or 13 and/or substitution with an amino acid in the D-conformation at position 20 or 21 compared to native glucagon.