The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Nov. 25, 2015
Applicant:
Hoffmann-la Roche Inc., Little Falls, NJ (US);
Inventors:
Per-Ola Freskgard, Renach BL, CH;
Eric A. Kitas, Aesch, CH;
Assignee:
Hoffmann-La Roche Inc., Little Falls, NJ (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2019.01); A61K 38/10 (2006.01); A61K 38/41 (2006.01); A61K 47/60 (2017.01); A61K 47/66 (2017.01); C07K 7/08 (2006.01); C07K 14/81 (2006.01); A61K 38/55 (2006.01); A61K 47/65 (2017.01); A61K 38/00 (2006.01);
U.S. Cl.
CPC ...
C07K 7/08 (2013.01); A61K 38/08 (2013.01); A61K 38/10 (2013.01); A61K 38/55 (2013.01); A61K 47/60 (2017.08); A61K 47/65 (2017.08); C07K 14/8142 (2013.01); A61K 38/00 (2013.01);
Abstract
Provided herein are peptides having dual-site BACE1 inhibitory activity, useful for the treatment of, for example Alzheimer's disease and diabetes. One such peptide is a dual-site BACE1 inhibitor, or a pharmaceutically acceptable salt thereof, binding to both an enzymatic active site and an catalytic domain of the BACE enzyme, and an exosite inhibitory part is connected to an active-site inhibitory part of the dual site BACE1 inhibitor by a linker.