The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
May. 14, 2018
Enanta Pharmaceuticals, Inc., Watertown, MA (US);
Guoqiang Wang, Belmont, MA (US);
Ruichao Shen, Belmont, MA (US);
Jiang Long, Wayland, MA (US);
Jun Ma, Belmont, MA (US);
Xuechao Xing, Wilmington, MA (US);
Yong He, Lexington, MA (US);
Brett Granger, Sudbury, MA (US);
Jing He, Somerville, MA (US);
Bin Wang, Brighton, MA (US);
Yat Sun Or, Watertown, MA (US);
Enanta Pharmaceuticals, Inc., Watertown, MA (US);
Abstract
The present invention discloses compounds of Formula (I), or pharmaceutically acceptable salts, ester, stereoisomer, tautomer, solvate, hydrate, or combination thereof: which inhibit the Apoptosis signal-regulating kinase 1 (ASK-1), which associated with autoimmune disorders, neurodegenerative disorders, inflammatory diseases, chronic kidney disease, cardiovascular disease. The present invention further relates to pharmaceutical compositions comprising the aforementioned compounds for administration to a subject suffering from ASK-1 related disease. The invention also relates to methods of treating an ASK-1 related disease in a subject by administering a pharmaceutical composition comprising the compounds of the present invention. The present invention specifically relates to methods of treating ASK-1 associated with hepatic steatosis, including non-alcoholic fatty liver disease (NAFLD) and non-alcohol steatohepatitis disease (NASH).