The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 16, 2020

Filed:

Sep. 23, 2016
Applicant:

The United States of America, As Represented BY the Secretary, Department of Health and Human Services, Bethesda, MD (US);

Inventors:

Kenneth A. Jacobson, Silver Spring, MD (US);

Anna Junker, Wallenhorst, DE;

Elisa Uliassi, Bologna, IT;

Evgeny Kiselev, Rockville, MD (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 401/06 (2006.01); C07D 401/10 (2006.01); C07D 401/14 (2006.01); C07D 211/18 (2006.01); C07D 417/14 (2006.01); C07D 405/14 (2006.01); C07D 409/14 (2006.01);
U.S. Cl.
CPC ...
C07D 401/10 (2013.01); C07D 211/18 (2013.01); C07D 401/06 (2013.01); C07D 401/14 (2013.01); C07D 405/14 (2013.01); C07D 409/14 (2013.01); C07D 417/14 (2013.01);
Abstract

Described are compounds, which are antagonists of the P2Yreceptor, for example, a compound of formula (I) in which ring A, R, R, R, and n are as described herein. Also provided are dendron conjugates comprising the compounds, and methods of using the compounds, including a method of treating a disorder, such as inflammation, diabetes, insulin resistance, hyperglycemia, a lipid disorder, obesity, a condition associated with metabolic syndrome, and asthma, and a method of antagonizing P2receptor activity in a cell.


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