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The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 10683269 B1

PDFFull Text
Date of Patent:
Jun. 16, 2020

Filed:

Mar. 17, 2017

2-cyanoisoindoline derivatives for treating cancer

Applicant:

Mission Therapeutics Limited, Cambridge, GB;

Inventors:

Karl Richard Gibson, Sandwich Kent, GB;

Alison Jones, Cambridge, GB;

Mark Ian Kemp, Cambridge, GB;

Andrew Madin, Cambridge, GB;

Martin Lee Stockley, Cambridge, GB;

Gavin Alistair Whitlock, Sandwich Kent, GB;

Michael D Woodrow, Cambridge, GB;

Keith Allan Menear, Storrington, GB;

Assignee:

MISSION THERAPEUTICS LIMITED, Cambridge, GB;

Attorney:
Primary Examiner:

Kristin A Vajda

Int. Cl.
CPC ...
C07D 209/44 (2006.01); C07D 403/10 (2006.01); C07D 403/04 (2006.01); C07D 401/04 (2006.01); C07D 471/04 (2006.01); C07D 413/04 (2006.01); C07D 401/12 (2006.01); C07D 413/12 (2006.01); C07D 409/12 (2006.01); A61P 35/00 (2006.01); C07D 519/00 (2006.01); C07D 403/14 (2006.01); C07D 487/04 (2006.01); C07D 401/06 (2006.01); C07D 405/12 (2006.01); C07D 401/14 (2006.01); C07D 413/14 (2006.01); C07D 413/10 (2006.01); C07D 403/12 (2006.01); C07D 417/12 (2006.01);
U.S. Cl.
CPC ...
C07D 209/44 (2013.01); A61P 35/00 (2018.01); C07D 401/04 (2013.01); C07D 401/06 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 405/12 (2013.01); C07D 409/12 (2013.01); C07D 413/04 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/12 (2013.01); C07D 471/04 (2013.01); C07D 487/04 (2013.01); C07D 519/00 (2013.01);
Abstract

The invention relates to novel compounds of formula I which are inhibitors of deubiquitylating enzymes (DUBs) and/or desumoylating enzymes. In particular, the invention relates to the inhibition of ubiquitin C-terminal hydrolase 7 or ubiquitin specific peptidase 7 (USP7). The invention further relates to methods for the preparation of these compounds and to their use in the treatment of cancer.

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