The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 16, 2020

Filed:

Jul. 22, 2014
Applicant:

Wisconsin Alumni Research Foundation, Madison, WI (US);

Inventors:

Glen S. Kwon, Madison, WI (US);

Hyunah Cho, Madison, WI (US);

Assignee:
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/337 (2006.01); A61K 31/436 (2006.01); A61K 31/395 (2006.01); A61K 9/06 (2006.01); A61K 47/34 (2017.01); A61K 9/00 (2006.01); A61P 35/00 (2006.01);
U.S. Cl.
CPC ...
A61K 47/34 (2013.01); A61K 9/0019 (2013.01); A61K 9/06 (2013.01); A61K 31/337 (2013.01); A61K 31/395 (2013.01); A61K 31/436 (2013.01); A61P 35/00 (2018.01);
Abstract

The invention provides a drug delivery system for a combination of therapeutic agents. The system includes a water soluble biodegradable ABA-type triblock copolymer that possesses thermosensitive gelation properties. The system can form a stable thermogel that includes a combination of therapeutic agents including, for example, rapamycin, paclitaxel, and 17-AAG. After administration to a subject, the drugs are released at a controlled rate from the thermogel, which biodegrades into non-toxic components. The polymer system can also function to increase the solubility and stability of drugs in the composition.


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