The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Nov. 30, 2016
Applicants:
Massachusetts Institute of Technology, Cambridge, MA (US);
Duke University, Durham, NC (US);
Inventors:
Benjamin David Auerbach, Buffalo, NY (US);
Mark Firman Bear, Boston, MA (US);
Laura Jane Stoppel, Cambridge, MA (US);
Robert J. Lefkowitz, Durham, NC (US);
Assignees:
Massachusetts Institute of Technology, Cambridge, MA (US);
Duke University, Durham, NC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/11 (2006.01); A61K 38/46 (2006.01); C12N 15/113 (2010.01); C12N 15/115 (2010.01); A61K 48/00 (2006.01);
U.S. Cl.
CPC ...
A61K 38/465 (2013.01); C12N 15/113 (2013.01); C12N 15/115 (2013.01); C12N 15/1138 (2013.01); A01K 2217/075 (2013.01); A01K 2217/077 (2013.01); A01K 2217/15 (2013.01); A01K 2227/105 (2013.01); A61K 48/00 (2013.01); C12N 2310/10 (2013.01); C12N 2310/11 (2013.01); C12N 2310/12 (2013.01); C12N 2310/14 (2013.01); C12N 2310/16 (2013.01); C12N 2310/3231 (2013.01); C12N 2310/3233 (2013.01); C12N 2310/531 (2013.01);
Abstract
Disclosed herein are novel methodologies of treating fragile X syndrome and related disorders by inhibiting mGlu-relevant signaling pathways via the reduction of β-arrestin2 protein levels or the diminution of mGluand β-arrestin2 protein interactions.