The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Sep. 10, 2018
Massachusetts Institute of Technology, Cambridge, MA (US);
Yizhou Dong, Dublin, OH (US);
Kevin Thomas Love, Boston, MA (US);
Robert S. Langer, Newton, MA (US);
Daniel Griffith Anderson, Framingham, MA (US);
Delai Chen, Cambridge, MA (US);
Yi Chen, Cambridge, MA (US);
Arturo Jose Vegas, Belmont, MA (US);
Akinleye C. Alabi, Ithaca, NY (US);
Yunlong Zhang, Cambridge, MA (US);
Massachusetts Intstitute of Technology, Cambridge, MA (US);
Abstract
Described herein are compounds and compositions characterized, in certain embodiments, by conjugation of various groups, such as lipophilic groups, to an amino or amide group of an amino acid, a linear or cyclic peptide, a linear or cyclic polypeptide, or structural isomer thereof, to provide compounds of the present invention, collectively referred to herein as 'APPLs'. Such APPLs are deemed useful for a variety of applications, such as, for example, improved nucleotide delivery. Exemplary APPLs include, but are not limited to, compounds of Formula (I), (II), (III), (IV), (V), and (VI), and salts thereof, as described herein: wherein m, n, p, R', R, R, R, R, R, R, Z, W, Y, and Z are as defined herein.