The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 16, 2020
Filed:
Mar. 29, 2018
Applicant:
University of South Carolina, Columbia, SC (US);
Inventor:
Edward L. D'Antonio, Bluffton, SC (US);
Assignee:
University of South Carolina, Columbia, SC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/352 (2006.01); A61K 31/5377 (2006.01); A61K 31/18 (2006.01); A61K 31/515 (2006.01); A61K 31/4545 (2006.01); A61K 31/519 (2006.01); A61P 33/00 (2006.01); A61K 31/4162 (2006.01); A61K 31/4439 (2006.01); A61K 31/473 (2006.01); A61K 31/444 (2006.01); A61K 31/381 (2006.01); A61K 31/357 (2006.01);
U.S. Cl.
CPC ...
A61K 31/5377 (2013.01); A61K 31/18 (2013.01); A61K 31/352 (2013.01); A61K 31/357 (2013.01); A61K 31/381 (2013.01); A61K 31/4162 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/4545 (2013.01); A61K 31/473 (2013.01); A61K 31/515 (2013.01); A61K 31/519 (2013.01); A61P 33/00 (2018.01); Y02A 50/414 (2018.01);
Abstract
Compounds discovered through a high-throughput screen, along with methods of use of the compounds, are provided. The compounds can be used to strongly inhibit key drug targets found in protozoan parasites, e.g., the targetglucokinase. Compounds include derivatives of N-phenylbenzenesulfonamide, barbituric acid, (R)-3-(piperidin-2-yl)pyridine, 3-nitro-2-phenyl-2H-chromene, 6-amino-3-methyl-4-phenyl-1,4-dihydropryranole[2,3-c]pyrazole-5-carbonitrile, and gossypol (2,2'-Bis(formyl-1,6,7-trihydroxy-5-isopropyl-3-methylnaphthalene).