The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2020
Filed:
Jul. 27, 2015
Inserm (Institut National DE LA Santé ET DE LA Recherche Médicale), Paris, FR;
Universite DE Montpellier, Montpellier, FR;
Centre Hospitalier Universitaire DE Montpellier, Montpellier, FR;
Centre National DE LA Recherche Scientifique (Cnrs), Paris, FR;
Jerome Moreaux, Montpellier, FR;
Guillaume Cartron, Montpellier, FR;
Caroline Bret, Montpellier, FR;
Angelos Constantinou, Montpellier, FR;
Philippe Pasero, Montpellier, FR;
INSERM(INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE), Paris, FR;
UNIVERSITE DE MONTPELLIER, Montpellier, FR;
CENTRE HOSPITALIER UNIVERSITAIRE DE MONTPELLIER, Montpellier, FR;
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (CNRS), Paris, FR;
Abstract
The present invention relates to a method of testing whether a patient suffering from arge B-cell lymphoma will respond or not to a DNA repair pathway inhibitor comprising: i) determining the expression level (ELi) of several genes Gi-Gn selected from table A in a biological sample obtained from said patient comparing the expression level (ELi) determined at step i) with a predetermined reference level (ELRi) iii) calculating the DNA repair score trough the following formula (I), wherein βi represent the regression β coefficient reference value for the gene Gi and Ci=1 if the expression of the gene Gi (ELi) is higher than the predetermined reference level (ELRi) or Ci=−1 if the expression of the gene (ELi) is lower than or equal to the predetermined reference level (ELRi) iv) comparing the score DNARS determined at step iii) with a predetermined reference value DNARSv) and concluding that the patient will respond to the treatment when the DNARS score is higher than the predetermined reference value DNARSor concluding that the patient will not respond to the treatment when the DNARS score is lower than the predetermined reference value DNARS.