The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2020
Filed:
Apr. 16, 2018
Biogen MA Inc., Cambridge, MA (US);
Samsung Bioepis, Yeonsu-gu, KR;
William C. Yang, Cary, NC (US);
Yao-Ming Huang, Cary, NC (US);
Kyle McElearney, Medford, MA (US);
Lia Tescione, Cambridge, MA (US);
James Lambropoulos, Cambridge, MA (US);
An Zhang, Cary, NC (US);
Valerie Liu Tsang, Cary, NC (US);
Thomas Ryll, Lexington, MA (US);
Sangil Lee, Incheon, KR;
Dae Sung Lee, Incheon, KR;
Biogen MA Inc., Cambridge, MA (US);
Samsung Bioepis, Yeonsu-gu, KR;
Abstract
The present invention pertains to a cell culture medium comprising media supplements that are shown to control recombinant protein glycosylation and/or cell culture in a controlled or modulated (shifted) temperature to control recombinant protein glycosylation and/or cell culture with controlled or modulated seed density to control recombinant protein glycosylation, and methods of using thereof. The present invention further pertains to a method of controlling or manipulating glycosylation of a recombinant protein of interest in a large scale cell culture.