The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2020
Filed:
May. 10, 2016
Applicants:
David Gordon Bermudes, Woodland Hills, CA (US);
David Quintero, Northridge, CA (US);
Inventors:
David Gordon Bermudes, Woodland Hills, CA (US);
David Quintero, Northridge, CA (US);
Assignee:
Other;
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 35/74 (2015.01); C07K 14/21 (2006.01); A61K 38/45 (2006.01); C12N 9/10 (2006.01); C12N 15/74 (2006.01); C07K 14/005 (2006.01); C07K 14/245 (2006.01); C07K 14/415 (2006.01); A61K 38/00 (2006.01); A61K 35/00 (2006.01);
U.S. Cl.
CPC ...
C12N 9/1077 (2013.01); A61K 35/74 (2013.01); C07K 14/005 (2013.01); C07K 14/245 (2013.01); C07K 14/415 (2013.01); C12Y 204/02036 (2013.01); A61K 38/00 (2013.01); A61K 2035/11 (2013.01); C07K 2319/00 (2013.01); C07K 2319/55 (2013.01); C12N 2750/10022 (2013.01); C12N 2750/10033 (2013.01);
Abstract
Bacteria with tumor-targeting capability express, surface displayed, secreted and/or released modified chimeric therapeutic proteins with enhanced therapeutic activity against a neoplastic tissue including solid tumors, lymphomas and leukemias. The bacteria may be attenuated, non-pathogenic, low pathogenic or a probiotic. The chimeric proteins may be protease sensitive and may optionally be further accompanied by co-expression of a secreted protease inhibitor as a separate molecule or as a fusion.