The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2020
Filed:
Aug. 28, 2013
Applicant:
Janssen Sciences Ireland Uc, Little Island, Co Cork, IE;
Inventors:
Koen Vandyck, Paal-Beringen, BE;
Stefaan Julien Last, Lint, BE;
Geert Rombouts, Borsbeek, BE;
Wim Gaston Verschueren, Berchem, BE;
Pierre Jean-Marie Bernard Raboisson, Rosieres, BE;
Assignee:
Janssen Sciences Ireland UC, Little Island, County Cork, IE;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 213/42 (2006.01); C07D 213/81 (2006.01); C07D 213/82 (2006.01); A61K 31/44 (2006.01); A61K 31/4402 (2006.01); A61K 31/4406 (2006.01); A61K 31/4409 (2006.01); C07C 311/37 (2006.01); C07C 311/14 (2006.01); C07C 311/16 (2006.01); C07C 311/20 (2006.01); C07C 311/51 (2006.01); A61K 31/18 (2006.01); A61K 31/337 (2006.01); A61K 31/341 (2006.01); A61K 31/351 (2006.01); A61K 31/4164 (2006.01); A61K 31/426 (2006.01); A61K 31/4453 (2006.01); A61K 31/4468 (2006.01); C07D 211/96 (2006.01); C07D 305/08 (2006.01); C07D 307/22 (2006.01); C07D 205/04 (2006.01); C07D 207/273 (2006.01); C07D 307/60 (2006.01); C07D 333/38 (2006.01); C07D 333/48 (2006.01); C07D 233/90 (2006.01); C07D 491/107 (2006.01); C07D 207/14 (2006.01); C07D 207/36 (2006.01); C07D 277/56 (2006.01); C07D 211/28 (2006.01); C07D 295/13 (2006.01); C07D 211/56 (2006.01); C07D 211/76 (2006.01); C07D 295/26 (2006.01); C07D 307/68 (2006.01); C07D 493/08 (2006.01); A61K 31/34 (2006.01); A61K 31/397 (2006.01); A61K 31/495 (2006.01); A61K 31/5375 (2006.01); A61K 31/55 (2006.01); C07D 223/06 (2006.01); C07D 233/84 (2006.01); C07D 309/14 (2006.01); A61K 31/401 (2006.01); A61K 45/06 (2006.01);
U.S. Cl.
CPC ...
C07C 311/37 (2013.01); A61K 31/18 (2013.01); A61K 31/337 (2013.01); A61K 31/34 (2013.01); A61K 31/341 (2013.01); A61K 31/351 (2013.01); A61K 31/397 (2013.01); A61K 31/401 (2013.01); A61K 31/4164 (2013.01); A61K 31/426 (2013.01); A61K 31/44 (2013.01); A61K 31/4453 (2013.01); A61K 31/4468 (2013.01); A61K 31/495 (2013.01); A61K 31/5375 (2013.01); A61K 31/55 (2013.01); A61K 45/06 (2013.01); C07C 311/14 (2013.01); C07C 311/16 (2013.01); C07C 311/20 (2013.01); C07C 311/51 (2013.01); C07D 205/04 (2013.01); C07D 207/14 (2013.01); C07D 207/273 (2013.01); C07D 207/36 (2013.01); C07D 211/28 (2013.01); C07D 211/56 (2013.01); C07D 211/76 (2013.01); C07D 211/96 (2013.01); C07D 213/42 (2013.01); C07D 213/81 (2013.01); C07D 213/82 (2013.01); C07D 223/06 (2013.01); C07D 233/84 (2013.01); C07D 233/90 (2013.01); C07D 277/56 (2013.01); C07D 295/13 (2013.01); C07D 295/26 (2013.01); C07D 305/08 (2013.01); C07D 307/22 (2013.01); C07D 307/60 (2013.01); C07D 307/68 (2013.01); C07D 309/14 (2013.01); C07D 333/38 (2013.01); C07D 333/48 (2013.01); C07D 491/107 (2013.01); C07D 493/08 (2013.01); C07C 2601/02 (2017.05); C07C 2601/04 (2017.05); C07C 2601/08 (2017.05); C07C 2601/14 (2017.05); C07C 2602/08 (2017.05); C07C 2602/10 (2017.05);
Abstract
Inhibitors of HBV replication of Formula (I) including stereochemically isomeric forms, and salts, hydrates, solvates thereof, wherein B, R, Rand Rhave the meaning as defined herein. The present invention also relates to processes for preparing said compounds, pharmaceutical compositions containing them and their use, alone or in combination with other HBV inhibitors, in HBV therapy.