The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2020
Filed:
Sep. 08, 2016
Applicant:
Clemson University, Clemson, SC (US);
Inventors:
Christopher Fernandez, Clifton, NJ (US);
Jeremy Mercuri, Piedmont, SC (US);
Assignee:
Clemson University Research Foundation, Clemson, SC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61L 27/36 (2006.01); A61F 2/44 (2006.01); A61L 27/38 (2006.01); C12N 5/00 (2006.01);
U.S. Cl.
CPC ...
A61L 27/3687 (2013.01); A61F 2/442 (2013.01); A61L 27/3612 (2013.01); A61L 27/3658 (2013.01); A61L 27/3683 (2013.01); A61L 27/3691 (2013.01); A61L 27/3834 (2013.01); A61L 27/3856 (2013.01); C12N 5/0018 (2013.01); A61L 2430/06 (2013.01); A61L 2430/38 (2013.01); C12N 2533/90 (2013.01); C12N 2537/00 (2013.01);
Abstract
Methods for developing a decellularized tissue and biomaterials for use as biomimetic grafts or in vitro cellular scaffolds formed with the decellularized tissue are described. The biomaterials are particularly well suited for use as an intervertebral disc graft. The decellularized tissue is formed from an intervertebral disc source tissue and can be substantially decellularized and substantially free of potential immunogenic material (e.g., DNA and RNA), while maintaining ECM materials including both glycosaminoglycan and collagen.