The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 09, 2020
Filed:
May. 18, 2016
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
National Yang-ming University, Taipei, TW;
Stanley N. Cohen, Stanford, CA (US);
Ning Deng, Palo Alto, CA (US);
Yanan Feng, San Jose, CA (US);
Tzu-Hao Cheng, Taipei, TW;
Yun-Yun Wu, Taipei, TW;
Wen-Chieh Hsieh, Taipei, TW;
The Board of Trustees of the Leland Stanford Junior University, Stanford, CA (US);
National Yang-Ming University, Taipei, TW;
Abstract
Aspects of the invention include methods of reducing the deleterious activity of a mutant extended nucleotide repeat (NR) containing target gene in a cell by contacting the cell with an effective amount of a nucleoside agent, as well as compositions used in such methods. The deleterious activity (e.g., toxicity and/or dis-functionality of products encoded thereby) of a mutant extended NR containing target gene may be reduced in a variety of different ways, e.g., by reducing (and in some instances differentially, including selectively, reducing) the production or activity of toxic expression products (e.g., RNA or protein) encoded by the target gene. Kits and compositions for practicing the subject methods are also provided.