The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2020
Filed:
Jan. 16, 2017
Applicants:
Tokushima University, Tokushima-shi, JP;
Oncotherapy Science, Inc., Kawasaki-shi, JP;
Inventors:
Assignees:
TOKUSHIMA UNIVERSITY, Tokushima-shi, JP;
ONCOTHERAPY SCIENCE, INC., Kawasaki-shi, JP;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/10 (2006.01); C07K 7/04 (2006.01); A61K 38/00 (2006.01); C07K 7/00 (2006.01); A61P 35/00 (2006.01); A61K 38/03 (2006.01);
U.S. Cl.
CPC ...
C07K 7/04 (2013.01); A61K 38/00 (2013.01); A61K 38/10 (2013.01); A61P 35/00 (2018.01); C07K 7/00 (2013.01); A61K 38/03 (2013.01);
Abstract
The present invention provides peptides containing a structure in which a portion of the dominant negative peptide of BIG3 which inhibits the interaction between BIG3 and PHB2 is substituted with stapling structure(s). Peptides of the present invention have excellent cell growth inhibitory actions. Furthermore, their cell growth inhibitory actions continue for a longer time than the actions of peptides without stapling structures. Therefore, these peptides have features suitable for clinical applications in cancer therapy.