The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2020
Filed:
Jan. 11, 2019
Epizyme, Inc., Cambridge, MA (US);
Richard Chesworth, Concord, MA (US);
Megan Alene Cloonan Foley, Somerville, MA (US);
Kevin Wayne Kuntz, Woburn, MA (US);
Lorna Helen Mitchell, Cambridge, MA (US);
Jennifer C. Petter, Stow, MA (US);
Carl Eric Schwartz, Lynnfield, MA (US);
EPIZYME, INC., Cambridge, MA (US);
Abstract
The present disclosure provides provides substituted isoxazole carboxamides having Formula (I), and the pharmaceutically acceptable salts and solvates thereof, wherein R, R, R, R, R, X, n, and m are defined as set forth in the specification. The present disclosure is also directed to the use of compounds of Formula I to treat a disorder responsive to the blockade of SMYD proteins such as SMYD3 or SMYD2. Compounds of the present disclosure are especially useful for treating cancer.