The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2020
Filed:
Dec. 14, 2017
Applicant:
Georgetown University, Washington, DC (US);
Inventors:
Esther H. Chang, Potomac, MD (US);
Kathleen F. Pirollo, Rockville, MD (US);
Assignee:
GEORGETOWN UNIVERSITY, Washington, DC (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 48/00 (2006.01); A61K 9/127 (2006.01); C12N 9/18 (2006.01); A61K 47/69 (2017.01);
U.S. Cl.
CPC ...
A61K 48/005 (2013.01); A61K 9/1272 (2013.01); A61K 47/6913 (2017.08); C12N 9/18 (2013.01);
Abstract
The present application provides methods of preventing and treating the toxic effects of exposure to organophosphate agents. In embodiments, targeted cationic liposome complexes delivering nucleic acid molecules encoding butyrylcholinesterase and a polyproline rich peptide are administered. Suitably, the administration is via inhalation or via aerosol. Also provided are cationic liposome complexes and methods of making the complexes for such administration.