The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2020
Filed:
Jun. 07, 2016
Ethicon Endo-surgery, Inc., Cincinnati, OH (US);
The General Hospital Corporation, Boston, MA (US);
Lee M. Kaplan, Wellesley, MA (US);
Nicholas Stylopoulos, Swampscott, MA (US);
Jason L. Harris, Lebanon, OH (US);
Dwight Henninger, Waynesville, OH (US);
Taylor W. Aronhalt, Loveland, OH (US);
James W. Voegele, Cincinnati, OH (US);
Ethicon Endo-Surgery, Inc., Cincinnati, OH (US);
The General Hospital Corporation, Boston, MA (US);
Abstract
Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.