The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Jun. 02, 2020

Filed:

Dec. 19, 2014
Applicant:

Biomed Valley Discoveries, Inc., Kansas City, MO (US);

Inventors:

Saurabh Saha, Wellesley Hills, MA (US);

Dean Welsch, Parkville, MO (US);

Gary DeCrescenzo, Parkville, MO (US);

Jeffrey James Roix, Boston, MA (US);

Assignee:

BIOMED VALLEY DISCOVERIES, INC., Kansas City, MO (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/4439 (2006.01); A61K 31/437 (2006.01); A61K 31/506 (2006.01); A61K 45/06 (2006.01); A61K 31/519 (2006.01); A61K 31/555 (2006.01); A61K 31/5377 (2006.01); A61K 31/517 (2006.01); A61K 31/428 (2006.01); A61K 31/44 (2006.01);
U.S. Cl.
CPC ...
A61K 31/4439 (2013.01); A61K 31/428 (2013.01); A61K 31/437 (2013.01); A61K 31/44 (2013.01); A61K 31/506 (2013.01); A61K 31/517 (2013.01); A61K 31/519 (2013.01); A61K 31/5377 (2013.01); A61K 31/555 (2013.01); A61K 45/06 (2013.01);
Abstract

The present invention provides, inter alia, methods of treating or ameliorating the effects of a cancer in a subject. The methods include administering to the subject an effective amount of (i) a first anti-cancer agent, which is BVD-523 or a pharmaceutically acceptable salt thereof and (ii) a second anti-cancer agent, which is a type 1 RAF inhibitor (such as dabrafenib) or another RAF inhibitor (such as regorafenib) or a pharmaceutically acceptable salt thereof, to treat or ameliorate the effects of the cancer. Also provided are pharmaceutical compositions and kits for treating or ameliorating the effects of a cancer in a subject.


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