The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jun. 02, 2020
Filed:
Jan. 15, 2019
Applicant:
Rhizen Pharmaceuticals SA, La Chaux-de-Fonds, CH;
Inventors:
Meyyappan Muthuppalaniappan, Hyderabad, IN;
Srikant Viswanadha, Hyderabad, IN;
Gayatri S. Merikapudi, Hyderabad, IN;
Swaroop K. Vakkalanka, La Chaux-de-Fonds, CH;
Assignee:
RHIZEN PHARMACEUTICALS SA, La Chaux-de-Fonds, CH;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
A61K 31/433 (2006.01); A61K 31/427 (2006.01); A61K 31/415 (2006.01); A61K 31/4439 (2006.01); A61K 31/496 (2006.01); A61K 31/5377 (2006.01); A61P 29/00 (2006.01); A61K 31/444 (2006.01); A61K 31/506 (2006.01); C07D 231/12 (2006.01); C07D 401/04 (2006.01); C07D 401/12 (2006.01); C07D 401/14 (2006.01); C07D 403/04 (2006.01); C07D 403/12 (2006.01); C07D 403/14 (2006.01); C07D 413/12 (2006.01); C07D 413/14 (2006.01); C07D 417/12 (2006.01); C07D 417/14 (2006.01); C07D 207/327 (2006.01); C07D 401/10 (2006.01); C07D 403/10 (2006.01); C07D 413/10 (2006.01); C07D 417/10 (2006.01); A61K 31/422 (2006.01); A61K 31/455 (2006.01); A61K 45/06 (2006.01); C07D 207/337 (2006.01); C07D 295/195 (2006.01); C12N 5/078 (2010.01);
U.S. Cl.
CPC ...
A61K 31/433 (2013.01); A61K 31/415 (2013.01); A61K 31/422 (2013.01); A61K 31/427 (2013.01); A61K 31/444 (2013.01); A61K 31/4439 (2013.01); A61K 31/455 (2013.01); A61K 31/496 (2013.01); A61K 31/506 (2013.01); A61K 31/5377 (2013.01); A61K 45/06 (2013.01); A61P 29/00 (2018.01); C07D 207/327 (2013.01); C07D 207/337 (2013.01); C07D 231/12 (2013.01); C07D 295/195 (2013.01); C07D 401/04 (2013.01); C07D 401/10 (2013.01); C07D 401/12 (2013.01); C07D 401/14 (2013.01); C07D 403/04 (2013.01); C07D 403/10 (2013.01); C07D 403/12 (2013.01); C07D 403/14 (2013.01); C07D 413/10 (2013.01); C07D 413/12 (2013.01); C07D 413/14 (2013.01); C07D 417/10 (2013.01); C07D 417/12 (2013.01); C07D 417/14 (2013.01); C12N 5/0634 (2013.01); C12N 2500/46 (2013.01); Y02A 50/422 (2018.01);
Abstract
Disclosed are novel calcium release-activated calcium (CRAC) channel inhibitors, methods for preparing them, pharmaceutical compositions containing them, and methods of treatment using them. The present disclosure also relates to methods for treating non-small cell lung cancer (NSCLC) with CRAC inhibitors, and to methods for identifying therapeutics for treating and of diagnosing cancer.