The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 26, 2020
Filed:
Jul. 06, 2015
Applicant:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Inventors:
Sarel Fleishman, Rehovot, IL;
Gideon Lapidoth, Rehovot, IL;
Maria Gabriele Pszolla, Rehovot, IL;
Christoffer Norn, Rehovot, IL;
Assignee:
Yeda Research and Development Co. Ltd., Rehovot, IL;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
G16B 15/00 (2019.01); G16B 20/00 (2019.01); G16B 35/00 (2019.01); G16C 20/60 (2019.01);
U.S. Cl.
CPC ...
G16B 15/00 (2019.02); G16B 20/00 (2019.02); G16B 35/00 (2019.02); G16C 20/60 (2019.02);
Abstract
A method for constructing a library of amino-acid sequences having a common structural fold, and a method for designing and selecting an amino-acid sequence having a desired affinity to a molecular surface of interest of a molecular entity, using the library, are provided herein. The methods are based on a stochastic sampling of backbone conformations and amino acid conservation patterns observed in experimentally available protein structures having the common structural fold.